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--- excess_use_of_barbiturate_cause_anemia [2025/02/12 11:43] – created admin
+++ excess_use_of_barbiturate_cause_anemia [2025/02/16 10:05] (current) – admin
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-Excess use of Barbiturates causes Anemia
+**Excess use of Barbiturates causes Anemia**
+  * Barbiturates are a class of sedative-hypnotic drugs.
+  * They are commonly used as antiepileptics (phenobarbital) and for the induction of general anesthesia (thiopental).
+  * Symptoms of barbiturate toxicity
+  - Difficulty thinking, decreased level of consciousness
+  - bradycardia or rapid and weak pulse
+  - vertigo, nausea, muscle weakness
+  - decreased temperature dilated or contracted pupils
+  - ANAEMIA
+  * Excessive use of barbiturate need to catabolize or metabolize this drug in our body
+  * Otherwise it can lead to toxicity of drug
+  * barbiturate drugs Metabolized / Catabolized By Cytochrome P450 microsome
+  -  it is an Enzyme
+  -  this enzyme needs Haem as Cofactor
+  * Drugs like barbiturates induce Haem synthesis.
+  * Use of haem here leads to haem deficiency towards heamoglobin of erythrocytes
+  * So decresed amount of normal erythrocytes
+  * So decrease normal haemoglobin level in erythrocytes
+  * So it leads to decrease oxygen carrying capacity of blood
+  * Barbiturates negatively impact the bone marrow’s ability to fulfill its role in erythrocyte production.
+  * It leads anaemia in person which use excessive amount of barbiturate
+  * Healthcare professionals measure haemoglobin Level and blood cell count of patients Before use of barbiturate as anesthetic drug
+----
+**Excess use of Barbiturates causes Anemia**
   * Barbiturates are sedative hypnotics which causes CNS depression.