Excess use of Barbiturates causes Anemia

• Barbiturates are a class of sedative-hypnotic drugs.
• They are commonly used as antiepileptics (phenobarbital) and for the induction of general anesthesia (thiopental).
• Symptoms of barbiturate toxicity

1. Difficulty thinking, decreased level of consciousness
2. bradycardia or rapid and weak pulse
3. vertigo, nausea, muscle weakness
4. decreased temperature dilated or contracted pupils
5. ANAEMIA

• Excessive use of barbiturate need to catabolize or metabolize this drug in our body
• Otherwise it can lead to toxicity of drug
• barbiturate drugs Metabolized / Catabolized By Cytochrome P450 microsome

1. it is an Enzyme
2. this enzyme needs Haem as Cofactor

• Drugs like barbiturates induce Haem synthesis.
• Use of haem here leads to haem deficiency towards heamoglobin of erythrocytes
• So decresed amount of normal erythrocytes
• So decrease normal haemoglobin level in erythrocytes
• So it leads to decrease oxygen carrying capacity of blood
• Barbiturates negatively impact the bone marrow’s ability to fulfill its role in erythrocyte production.
• It leads anaemia in person which use excessive amount of barbiturate
• Healthcare professionals measure haemoglobin Level and blood cell count of patients Before use of barbiturate as anesthetic drug

Excess use of Barbiturates causes Anemia

• Barbiturates are sedative hypnotics which causes CNS depression.
• Excessive use of barbiturate need to catabolize or metabolize this
• drug in our body Otherwise it can lead to toxicity of drug
• barbiturate drugs Metabolized / Catabolized By Cytochrome P450

1. it is an Enzyme
2. this enzyme needs Haem as Cofactor

• Drugs like barbiturates induce Haem synthesis.
• Use of haem here leads to haem deficiency towards heamoglobin
• So decresed amount of normal erythrocytes
• Therefore decrease normal haemoglobin level in erythrocytes
• It leads to decrease oxygen carrying capacity of blood
• Barbiturates negatively impact the bone marrow’s ability to
• fulfill its role in erythrocyte production.
• It leads anaemia in person which use excessive amount of barbiturate
• Healthcare professionals measure haemoglobin Level and blood cell count of patients Before use of barbiturate as anesthetic drug
• Excessive use of barbiturates can lead to aplastic anemia and megaloblastic anemia in some cases.

1. Aplastic Anemia – Barbiturates, particularly phenobarbital, have been linked to bone marrow suppression, which can lead to aplastic anemia.
2. Megaloblastic Anemia – Long-term barbiturate use can interfere with folate metabolism, leading to a deficiency.This results in megaloblastic anemia, where red blood cells become abnormally large .