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Muscle glycogen cannot contribute to blood glucose.
- Glucose-6-phosphatase converts glucose-6-phosphate to glucose
- Muscle tissue lacks glucose-6-phosphatase enzyme(this enzyme is present in liver) so it cannot convert glucose-6-phosphate to glucose
- glucose-6-phosphate goes to liver for formation of glucose so muscle tissue cannot directly contribute for blood glucose
- Glucose-6-phosphate undergoes glycosis in muscle tissue to produce ATP for muscle contraction