Muscle glycogen cannot contribute to blood glucose.
- Glucose-6-phosphatase converts glucose-6-phosphate to glucose
- Muscle tissue lacks glucose-6-phosphatase enzyme(this enzyme is present in liver) so it cannot convert glucose-6-phosphate to glucose
- Glucose-6-phosphate, which is release from muscle glycogen, will goes to liver and converted to glucose.
- So muscle tissue cannot directly contribute for blood glucose, it's need help of liver enzyme for coversion from glucose - 6 phosphate to glucose.
- Glucose-6-phosphate undergoes glycolysis in muscle tissue to produce ATP for muscle contraction