LDL is metabolised via the LDL receptor.

• Low-density lipoprotein (LDL) is metabolized via the LDL receptor (LDLR) pathway, which plays a crucial role in cholesterol homeostasis.
• LDL binds to LDL receptors on the surface of hepatocytes and other cells leading to receptor-mediated endocytosis.
• Inside the cell, LDL is transported to lysosomes, where it is broken down to release free cholesterol for cellular use.
• This process helps regulate blood cholesterol levels.
• defects in LDL receptor function can lead to conditions like familial hypercholesterolemia.