Fibrinogen estimation can not be done by serum

• FIBRINOGEN HAS A MOLECULAR WEIGHT OF 3,40,000 D AND IS SYNTHESIZED BY THE LIVER.FIBRINOGEN LEVEL IN BLOOD IS 200-400 MG/DL
• SERUM IS OBTAINED AFTER BLOOD CLOTTING, DURING WHICH FIBRINOGEN IS CONVERTED INTO FIBRIN AS PART OF THE CLOTTING PROCESS.
• WHEN WE REMOVE BLOOD CLOTT WE ALSO REMOVE FIBRINOGEN IN THE CLOTT.
• SO THAT , WE ARE NOT ABLE TO ESTIMATE FRIBRENOGEN FROM SERUM