WHY FASTING BLOOD SAMPLE IS REQUIRED FOR COMPLETE LIPID PROFILE EVALUATION ?
ABSORPTION OF LIPIDS MIXED MICELLE FORMATION
- 2-Monoglycerides + LCFA + Cholesterol + Phospholipid → Incorporate into Molecular aggregates → form Micelle.
- Micelles→ Spherical Particles having Hydrophylic Exterior & Hydrophobic Interior core.
- Essential for absorption of Vit. A,D &K.
- Aligned at microvilli of Jejunal Mucosa & gets Absorbed Passively by Diffusion into Intestinal Mucosal Layer.
ENTEROHEPATIC CIRCULATION OF BILE SALTS
- Bile Salts → Reabsorbed from Ileum & returned to Liver.
- Around 98% dietary lipids are Absorbed
RE-ESTERIFICATION Inside Intestinal Mucosa LCFA→ Re-esterify→ form Triglyceride. LCFA→ Activated by Thiokinase/Acyl CoA Synthetase→ form Fatty Acyl CoA. 2*( Fatty Acyl CoA) + Mono acyl glycerol→ Triglyceride Free glycerol absorbed from Intestinal Lumen Directly. So, free glycerol Not Available for Re-Esterification
CHYLOMICRON FORMATION
- Formed by Incorporation of:
- Triacylglycerol
- Cholesterol ester
- Phospholipids
- Apo Protein B48 & Apo-A
- Chylomicron is now transported from intestinal mucosa Into Lymph Circulation through Lacteals.
- Hence Normally, Serum may appear Milky After intake of High Fat Meal.
