Deficiancy of Lipoprotein lipase results in hypertriglyceridemia

• The enzyme lipoprotein lipase (LpL) is located at the endothelial layer of capillaries of adipose tissue, muscles and heart; but not in liver.
• Apo C-II present in the chylomicrons activates the LpL .
• The LpL hydrolyzes triglycerides present in chylomicrons into fatty acids and glycerol.
• Muscle or adipose tissue cells take up the liberated fatty acids.
• Hence deficiency of lipoprotein lipase leads to high triglycerides levels in blood.