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| ldl_is_metabolised_via_the_ldl_receptor [2025/02/07 05:59] – created admin | ldl_is_metabolised_via_the_ldl_receptor [2025/02/11 02:02] (current) – admin | ||
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| - | Low-density lipoprotein (LDL) is metabolized via the LDL receptor (LDLR) pathway, which plays a crucial role in cholesterol homeostasis. LDL binds to LDL receptors on the surface of hepatocytes and other cells, leading to receptor-mediated endocytosis. Inside the cell, LDL is transported to lysosomes, where it is broken down to release free cholesterol for cellular use. This process helps regulate blood cholesterol levels, and defects in LDL receptor function can lead to conditions like familial hypercholesterolemia. | + | **LDL is metabolised via the LDL receptor.** |
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| + | * Low-density lipoprotein (LDL) is metabolized via the LDL receptor (LDLR) pathway, which plays a crucial role in cholesterol homeostasis. | ||
| + | * LDL binds to LDL receptors on the surface of hepatocytes and other cells leading to receptor-mediated endocytosis. | ||
| + | * Inside the cell, LDL is transported to lysosomes, where it is broken down to release free cholesterol for cellular use. | ||
| + | * This process helps regulate blood cholesterol levels. | ||
| + | * defects in LDL receptor function can lead to conditions like familial hypercholesterolemia. | ||
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