**Deficiancy of Lipoprotein lipase results in hypertriglyceridemia**

  * The enzyme lipoprotein lipase (LpL) is located at the endothelial layer of capillaries of adipose tissue, muscles and heart; but not in liver.
  * Apo C-II present in the chylomicrons activates the LpL .
  * The LpL hydrolyzes triglycerides present in chylomicrons into fatty acids and glycerol. 
  * Muscle or adipose tissue cells take up the liberated fatty acids.
  * Hence deficiency of lipoprotein lipase leads to high triglycerides levels in blood.