**ADIPOSE TISSUE - TWO TYPES**
  - **WHITE ADIPOSE TISSUE** - STORE ENERGY
  - **BROWN ADIPOSE TISSUE** - GENERATION OF HEAT
  * PROTEIN IN THE MITOCHONDRIA OF THE BROWN TISSUE **THERMOGENIN** (also called UNCOUPLING PROTEIN) THE UNCOUPLING OF PROTON FLOW RELEASES THE ENERGY OF THE ELECTROCHEMICAL GRADIENT OF THE PROTON AS HEAT
  * THE BROWN TISSUE PROVIDE THE NONSHIVERING THERMOGENISIS
  * NONSHIVERING THERMOGENISIS → HORMONAL STIMULUS PRODUCING HEAT WITHOUT THE ASSOCIATION OF MUSCLES OF SHIVERING
  * THERMOGENISIS START BY RELEASE OF FREE FATTY ACID FROM TRIGLYCERIDE (ADIPOCYTE  STORAGE)
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  * THE BROWN ADIPOSE TISSUE SHOWS THE UNCOUPLED PROTEIN EXPRESSION.THE MITOCHONDRIA IN THE BROWN ADIPOSE TISSUE CONTAIN THE PROTEIN CALLED THERMOGENIN
  * WHEN THE NOREPINEPHRINE IS RELEASED IN RESPONSE TO COLD SENSATIONS BIND TO THE ADRENERGIC RECEPTOR ON THE SURFACE OF THE BROWN
  * ADIPOCYTE TRIGGER THE ACTIVATION OF THE cAMP AND FURTHER ACTIVATION OF THE cAMP PROTEIN DEPENDENT KINASE
  * THIS RESULTS IN THE PHOSPHORYLATION AND HORMONE SENSITIVE LIPASE
  * THE FREE FATTY ACID RELEASED BIND TO THERMOGENIN TRIGGERING THE DISSIPATION OF THE PROTON GRADIENT
  * THUS , THE PHOSPHORYLATION IS UNCOUPLED FROM OXIDATION LEADING TO THE RELEASE OF ENERGY AS HEAT