Show pageOld revisionsBacklinksBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. **Excess use of Barbiturates causes Anemia** * Barbiturates are a class of sedative-hypnotic drugs. * They are commonly used as antiepileptics (phenobarbital) and for the induction of general anesthesia (thiopental). * Symptoms of barbiturate toxicity - Difficulty thinking, decreased level of consciousness - bradycardia or rapid and weak pulse - vertigo, nausea, muscle weakness - decreased temperature dilated or contracted pupils - ANAEMIA * Excessive use of barbiturate need to catabolize or metabolize this drug in our body * Otherwise it can lead to toxicity of drug * barbiturate drugs Metabolized / Catabolized By Cytochrome P450 microsome - it is an Enzyme - this enzyme needs Haem as Cofactor * Drugs like barbiturates induce Haem synthesis. * Use of haem here leads to haem deficiency towards heamoglobin of erythrocytes * So decresed amount of normal erythrocytes * So decrease normal haemoglobin level in erythrocytes * So it leads to decrease oxygen carrying capacity of blood * Barbiturates negatively impact the bone marrow’s ability to fulfill its role in erythrocyte production. * It leads anaemia in person which use excessive amount of barbiturate * Healthcare professionals measure haemoglobin Level and blood cell count of patients Before use of barbiturate as anesthetic drug ---- **Excess use of Barbiturates causes Anemia** * Barbiturates are sedative hypnotics which causes CNS depression. * Excessive use of barbiturate need to catabolize or metabolize this * drug in our body Otherwise it can lead to toxicity of drug * barbiturate drugs Metabolized / Catabolized By Cytochrome P450 - it is an Enzyme - this enzyme needs Haem as Cofactor * Drugs like barbiturates induce Haem synthesis. * Use of haem here leads to haem deficiency towards heamoglobin * So decresed amount of normal erythrocytes * Therefore decrease normal haemoglobin level in erythrocytes * It leads to decrease oxygen carrying capacity of blood * Barbiturates negatively impact the bone marrow’s ability to * fulfill its role in erythrocyte production. * It leads anaemia in person which use excessive amount of barbiturate * Healthcare professionals measure haemoglobin Level and blood cell count of patients Before use of barbiturate as anesthetic drug * Excessive use of barbiturates can lead to aplastic anemia and megaloblastic anemia in some cases. - Aplastic Anemia – Barbiturates, particularly phenobarbital, have been linked to bone marrow suppression, which can lead to aplastic anemia. - Megaloblastic Anemia – Long-term barbiturate use can interfere with folate metabolism, leading to a deficiency.This results in megaloblastic anemia, where red blood cells become abnormally large . {{ :img_4092.jpeg?400 |}}