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-                  +|[[clinical_biochemistry_section|Home]]|[[clinical_biochemistry|]]|[[examination_procedures|]]|
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-[[clinical_biochemistry_section|Home]]+
  
-                Urea Examination Procedure + 
-               +                Urea Examination Procedure              
 **1.Purpose of examination:**  **1.Purpose of examination:** 
 ● Urea  estimation from serum or plasma by Urease Method. ● Urea  estimation from serum or plasma by Urease Method.
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 **11.Performance Characteristics:**  **11.Performance Characteristics:** 
-**Linearity**:  3 to 128 mg/dL+  * **Linearity**:  3 to 128 mg/dL
 This assay is linear across the analytical measuring interval of 3 to 128 mg/dL for serum. This assay is linear across the analytical measuring interval of 3 to 128 mg/dL for serum.
 Automated Dilution Protocol: Automated Dilution Protocol:
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 Manual Dilution Procedure: Manual Dilution Procedure:
 Dilute the specimen with saline (0.85% to 0.90% NaCl). Enter the dilution factor in the Patient or Control order screen Dilute the specimen with saline (0.85% to 0.90% NaCl). Enter the dilution factor in the Patient or Control order screen
-**The limit of detection (LOD):** 3 mg/dl +  * **The limit of detection (LOD):** 3 mg/dl 
-**The limit of quantification(LOQ):** 3 mg/dL +  * **The limit of quantification(LOQ):** 3 mg/dL 
-**Unit**: mg/dl+  * **Unit**: mg/dl
  
 **Normal and critical ranges:** **Normal and critical ranges:**
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   * Increases in urea nitrogen may be due to increased production or decreased excretion. Urea nitrogen is useful in assessing renal function, especially with serum creatinine.   * Increases in urea nitrogen may be due to increased production or decreased excretion. Urea nitrogen is useful in assessing renal function, especially with serum creatinine.
   * Urea nitrogen clearance and urea nitrogen/creatinine ratio in serum are useful clinically to assess glomerular filtration rate (GFR) and volume depletion. Urea nitrogen is used before, during and after dialysis treatment to quantify an individual’s urea clearance during a single dialysis.   * Urea nitrogen clearance and urea nitrogen/creatinine ratio in serum are useful clinically to assess glomerular filtration rate (GFR) and volume depletion. Urea nitrogen is used before, during and after dialysis treatment to quantify an individual’s urea clearance during a single dialysis.
-**Interference and cross reaction:**+**13.Interference and cross reaction:**
 The Following analytes were tested up to the levels indicated at Direct Bilirubin concentrations of 0.14mg/dl and 5.03 mg/dl, and found not to interfere: The Following analytes were tested up to the levels indicated at Direct Bilirubin concentrations of 0.14mg/dl and 5.03 mg/dl, and found not to interfere:
   - No interference from Bilirubin up to 30 mg/dL    - No interference from Bilirubin up to 30 mg/dL 
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   * Software backup    * Software backup 
   * Machine raw data   * Machine raw data
 +  * 
 **14.Storage & Disposal of waste:** Follow storage & discard procedure **14.Storage & Disposal of waste:** Follow storage & discard procedure
-*15.*Environmental & Safety control:**+ 
 +**15.Environmental & Safety control:**
   * Follow the universal work precautions.    * Follow the universal work precautions. 
   * Do not use component beyond the expiration date.   * Do not use component beyond the expiration date.
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 **19References:** **19References:**
-Talke H, Schubert GE.Kliniscat  +  - Talke H, Schubert GE.Kliniscat  
-Teitz NW editer clinical gide for laboratory tests (3rd edi) +  - Teitz NW editer clinical gide for laboratory tests (3rd edi) 
-US department of labor,Occupational safety and health administration. +  - US department of labor,Occupational safety and health administration. 
-Burtis CA,Ashwood ER,editors,Tietz Textbook of clinical chemistry.+  - Burtis CA,Ashwood ER,editors,Tietz Textbook of clinical chemistry.
  
 +|**Printed copy of this document is considered uncontrolled.** It should be compared with controlled electronic copy before use|
  
 +^ Name of Laboratory : Laboratory Services Sir T. Hospital (LSSTH),Bhavnagar ^^^^
 +^Document No.1^**Document Name**: Urea Examination Procedure^**Unique ID**:LSSTH /BIOCHEM/ SOP-5^^
 +^Issue No. : 01^Issue Date :30/04/2024^Page No.^^
 +^Amend No.^ Amend Date ^Prepared by: Section Incharge^Approved & Issued by: HOD,Biochemistry^